کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622495 | 1494523 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The possible mechanism of hydroxytyrosol on reducing uric acid levels
ترجمه فارسی عنوان
مکانیسم امکان هیدروکسی تیروزول بر کاهش میزان اسید اوریک
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
In this study, the inhibitory effect of hydroxytyrosol against xanthine oxidase (XOD) by in vivo animal model and in vitro inhibition assay was analysed. The results showed that hydroxytyrosol could reduce uric acid in rat serum, inhibit XOD activity in rat liver, and adjust the mRNA transcription of the renal uric acid transporters URAT1, GLUT9, OAT1, UAT and ABCG2 towards normal in the transcription level. Hydroxytyrosol was observed as an inhibitor of XOD activity, which's IC50 value of restraining XOD activity was 8.75â¯mM. Circular dichroism (CD) spectroscopy indicated that the secondary structures of XOD were changed after incubation with hydroxytyrosol. The docking simulation showed that hydroxytyrosol could enter into the active site of XOD and form hydrogen bonds with amino acid residues (such as ARG880, GLU1261 and THR1010). The results suggested that hydroxytyrosol could be a potential XOD inhibitor for hyperuricaemia treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 319-326
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 319-326
نویسندگان
Yin Wan, Yu-Xi Liang, Bin Zou, Gui-Ming Fu, Ming-Yong Xie,