کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623092 | 1494541 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural elucidation, chain conformation and immuno-modulatory activity of glucogalactomannan from cultured Cordyceps sinensis fungus UM01
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural elucidation, chain conformation and immuno-modulatory activity of glucogalactomannan from cultured Cordyceps sinensis fungus UM01 Structural elucidation, chain conformation and immuno-modulatory activity of glucogalactomannan from cultured Cordyceps sinensis fungus UM01](/preview/png/7623092.png)
چکیده انگلیسی
The chemical structure, chain conformation, and immuno-modulatory activity of polysaccharide from mycelium Cordyceps sinensis fungus UM01 were investigated. The molecular weights and the intrinsic viscosity of purified polysaccharide (UM01-S4) were determined as 22,559âDa and 5.09âmL/g, respectively. Using the polymer solution theory, UM01-S4 has a sphere-like conformation in aqueous NaCl at 35â°C. The chemical structure of UM01-S4 contains an α-(1â2)-Manp core. The side chains were composed of β-(1â2)-Galf, β-(1â4)-Glcp, α-GalpA, and α-Manp units, which attached to the mannan core at the O-6 position. The immuno-modulatory assays showed that UM01-S4 exhibited good activities, including macrophages proliferation, phagocytosis, and release of NO and cytokines. The mechanism underlying the macrophage regulation of UM01-S4 might be related to the activation of the MAPK and NF-κB signalling pathways. Thus, mycelium of C. sinensis UM01 could be used as a natural immune-stimulating agent in functional food areas and pharmaceutical industries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 174-185
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 174-185
نویسندگان
Kit-Leong Cheong, Lan-Zhen Meng, Xian-Qiang Chen, Lan-Ying Wang, Ding-Tao Wu, Jing Zhao, Shao-Ping Li,