کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623118 | 1494544 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiovascular effects induced by northeastern Brazilian red wine: Role of nitric oxide and redox sensitive pathways
ترجمه فارسی عنوان
اثرات قلبی عروقی ناشی از شراب قرمز برزیلی شمال شرقی: نقش مسیرهای حساس اکسید نیتریک و حساسیت به باززایی
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Red wines have been shown to protect the vascular system by increasing the endothelial formation of nitric oxide (NO). This study investigated the vasoactive properties of an alcohol-free Cabernet-Sauvignon northeastern Brazilian red wine - RIOSOL (RSCS) extract. The polyphenolic-rich RSCS contained 4.2âmg GAE/L of polyphenols, and its major compounds included quercetin, myricetin and kaempferol. In normotensive conscious rats, RSCS produced hypotension and tachycardia, which were attenuated by the endothelial NO synthase inhibitor (eNOS), L-NAME. In addition, after 2 weeks of oral treatment, RSCS reduced arterial pressure in L-NAME-treated hypertensive rats. RSCS caused NO-mediated relaxations in phenylephrine contracted mesenteric artery rings, and induced the formation of NO and superoxide anions and a redox-sensitive phosphorylation of Akt and eNOS in cultured endothelial cells. In conclusion, the findings indicate that an alcohol-free lyophilized RSCS induced hypotension and endothelium-dependent vasorelaxation as a consequence of the activation of the Akt-eNOS-NO pathway in a redox-sensitive manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 82-92
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 82-92
نویسندگان
Thais P. Ribeiro, Aurylene C. Oliveira, Leonidas G. Mendes-Junior, Karime C. França, Lia S. Nakao, Valérie B. Schini-Kerth, Isac A. Medeiros,