کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623517 | 1494546 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Korean red ginseng protects against doxorubicin-induced testicular damage: An experimental study in rats
ترجمه فارسی عنوان
جینسنگ قرمز کره ای از آسیب های بیضه ناشی از دوکسوروبیسین محافظت می کند: یک مطالعه تجربی در موش صحرایی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The protective effects of Korean red ginseng (KRG; Panax ginseng Meyer) aqueous extract against doxorubicin (DOX)-induced testicular damage in rats was investigated. DOX (1âmgâ
mLâ1â
kgâ1â
weekâ1) was administrated intraperitoneally for 8 weeks and KRG extract was administrated orally for 9 weeks (100 or 200âmg/kg/day). The serum sex hormone levels, sperm kinematic parameters, histopathological parameters and protein expression levels were determined. DOX distinctly damaged the histology of the rat testes and decreased the sex hormonal levels, spermatogenesis, seminiferous tubular diameter, and testes weight. Further, the protein expression levels of peroxiredoxin, glutathione-S-transferase, nectin-2, inhibin-α, and cAMP response element binding protein were suppressed in DOX-treated rats. In contrast, KRG extract ameliorated the changes induced by DOX. Data indicated that KRG ameliorated DOX-induced testicular damage in rats by modulating the antioxidant system and hormonal imbalance. In conclusion, KRG can be used as a functional food and/or adjuvant for the prevention of reproductive damage caused by DOX.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 96-107
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 96-107
نویسندگان
Spandana Rajendra Kopalli, Yu-Jin Won, Seock-Yeon Hwang, Kyu-Min Cha, Sang-Yoon Kim, Chang-Kyun Han, Seung-Ho Lee, Jae-Yup Hong, Si-Kwan Kim,