کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623725 | 1494544 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxyresveratrol: A bioavailable dietary polyphenol
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
To evaluate the potential of oxyresveratrol (OXY), a dietary polyphenol with various health-promoting activities as a nutraceutical/functional food ingredient, its absolute oral bioavailability (F) was examined in Sprague-Dawley rats. Upon single intravenous administration (15âµmol/kg), rapid clearance (Cl) and short mean transit time (MTT) was observed. Dose-escalation to 90âµmol/kg did not alter its Cl and MTT significantly. After single oral administration (100âµmol/kg), although its F was only ~10%, OXY was absorbed rapidly and displayed long residence in systemic circulation. Dose-escalation to 400âµmol/kg brought ~60% and 100% increase in F and dose-normalized maximal plasma concentration (Cmax), respectively. One-week daily dosing (100âµmol/kg) did not cause substantial change in F and Cmax. Although OXY possessed slower Cl, its oral plasma exposure was comparable to RES. As OXY was orally bioavailable, further development of OXY as a nutraceutical/functional food ingredient is warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 122-131
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 122-131
نویسندگان
Wan Chen, Samuel Chao Ming Yeo, Mai Gamal Ahmed Ahmed Elhennawy, Hai-Shu Lin,