کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624240 1494550 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways
چکیده انگلیسی
Phellinus linteus is a mushroom with a variety of biological functions, such as antitumor and immunomodulating activities. P. linteus grown on germinated brown rice (PBR) feeding significantly decreased colon cancer metastasis to the lung and overall tumor size. In biomarker analysis, PBR showed significant anti-metastatic, anti-proliferative and pro-apoptotic activities. Detailed mechanistic studies highlighted that PBR strongly modulated MMP-2 and -9 activities and apoptotic biomarkers as well as decreased NF-κB, β-catenin, and mitogen-activated protein kinase (MAPK) expression. Together, these findings suggest that PBR is effective in preventing CRC by suppressing metastasis and proliferation and inducing apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 14, April 2015, Pages 289-298
نویسندگان
,