کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624558 | 1494550 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice](/preview/png/7624558.png)
چکیده انگلیسی
Ishizuchi dark tea is a microorganism-fermented tea produced in Ehime, Japan. We herein describe the anti-allergic effect of Ishizuchi dark tea. The water extract from Ishizuchi dark tea suppressed degranulation of RBL-2H3 cells in a dose-dependent manner with no apparent cytotoxicity. Fractionation and β-hexosaminidase release assay of the tea components revealed theabrownins as the major bioactive substance in Ishizuchi dark tea. Phosphorylation of Syk, a tyrosine kinase, tended to be suppressed by treating RBL-2H3 cells with theabrownins. In addition, Ishizuchi dark tea suppressed an allergic symptom in the Cry j1-induced pollinosis model mice. Taken together, these data indicated that Ishizuchi dark tea would be a beneficial functional food with an anti-allergic effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 14, April 2015, Pages 659-669
Journal: Journal of Functional Foods - Volume 14, April 2015, Pages 659-669
نویسندگان
Michiyo Kondo, Kosuke Nishi, Takuya Sugahara,