کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624592 | 1494553 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
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کلمات کلیدی
CAPEIC50HPLC-MSnAntitumoural activity5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridinecaffeic acid phenethyl ester - اسید کافئیک اسید فین الی استرBrdU - بروموداکسی اوریدینCAM - ساخت به کمک کامپیوترCancer - سرطانCancer metabolism - سوخت و ساز سرطانhigh-performance liquid chromatography-mass spectrometry - طیف سنجی جرم کروماتوگرافی مایع با کارایی بالاChicken chorioallantoic membrane - غشای کوریوالانتائی مرغAntiangiogenic activity - فعالیت ضد انعقادیhalf maximal inhibitory concentration - نیمه حداکثر غلظت مهاری
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 160-171
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 160-171
نویسندگان
Ricardo Silva-Carvalho, Vera Miranda-Gonçalves, Ana Margarida Ferreira, Susana M. Cardoso, AbÃlio J.F.N. Sobral, Cristina Almeida-Aguiar, Fátima Baltazar,