کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624623 1494553 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenolic compounds oleuropein and hydroxytyrosol exert differential effects on glioma development via antioxidant defense systems
ترجمه فارسی عنوان
ترکیبات فنلی اولئوروپین و هیدروکسی تیروزول اثرات متفاوتی را در توسعه گلیوما بوسیله سیستم های دفاع ضد عفونی اعمال می کنند
کلمات کلیدی
استرس اکسیداتیو، سیستم دفاع آنتی اکسیدان، گلیوما، هیدروکسی تیروئول، اولوروپین، رشد تومور،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Oxidative stress is involved in many of the stages of tumorigenesis, and the administration of exogenous antioxidants seems to modulate them. Thus, it has been described that oleuropein and hydroxytyrosol exert important anti-cancer activities. We analyse in vivo the anti-tumor properties of both phenolic compounds in an animal model of glioma, and their effects on oxidative stress, enzymatic and non-enzymatic antioxidant defence systems and on several biochemical biomarkers. Hydroxytyrosol, but not oleuropein nor the mixture of both compounds, inhibits tumor growth through mechanisms that involve enzymatic and non-enzymatic antioxidant defences, as demonstrated by a decrease in lipid peroxidation and protein oxidation levels. Furthermore, hydroxytyrosol maintains the non-enzymatic antioxidants as in healthy animals, and positively modifies the enzymatic antioxidants. However, hydroxytyrosol probably acts not as an antioxidant, but through other mechanisms that only indirectly modify the redox status. Finally, these compounds yield few adverse effects related to changes in hepatic enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 221-234
نویسندگان
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