کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624681 | 1494553 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity
ترجمه فارسی عنوان
عصاره مایع منی فوق بحرانی دو مرحله ای از رزماری با افزایش فعالیت ضد انعقادی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Previously, carnosic acid and carnosol have demonstrated anti-proliferative activity against different types of cancer. To obtain extracts enriched in these two key phenolic compounds, two different processes have been developed in the present work based on the use of two-step sequential supercritical fluid extraction (SFE). By removing the interfering, less active fractions in a first step (150 or 300 bar, 40°C, neat CO2, 60âmin), suitable enrichment is achieved in the second step (150 bar, 40°C, CO2 + 7% ethanol, 120âmin), and this leads to carnosic acid concentrations in the extract as high as 40% of total dry weight, which are among the highest concentrations that have been described with this type of process. The enriched extracts were tested against the HT-29 human adenocarcinoma cell line, showing enhancement of their antiproliferative activity by approximately 3-fold compared to previously reported SFE rosemary extracts and higher inhibitory effects at lower concentrations (30âµg mLâ1 of extract). Thus, the proposed two-step SFE process effectively improves the carnosic acid and carnosol recovery in shorter processing times (180âmin vs. 300âmin). Moreover, the obtained extracts possess higher anti-proliferative activity and consume less solvent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 293-303
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 293-303
نویسندگان
Andrea del Pilar Sánchez-Camargo, Alberto Valdés, Giuseppe Sullini, Virginia GarcÃa-Cañas, Alejandro Cifuentes, Elena Ibáñez, Miguel Herrero,