کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624765 | 1494554 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice](/preview/png/7624765.png)
چکیده انگلیسی
In this study, the effects of Lactobacillus rhamnosus CCFM0528, a new probiotic strain isolated by our laboratory, on glucose tolerance, hyperglycemia and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice were studied. The results indicate that L. rhamnosus CCFM0528 significantly decreased fasting and postprandial 2-h blood glucose, glycosylated hemoglobin (HbA1c), endotoxin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) levels compared with the control group (Pâ<0.05). However, the values for insulin, glycogen, interleukin-4 (IL-4), and interleukin-10 (IL-10) were effectively increased at 13âweeks (Pâ<0.05). The cytokine gene expressions in spleen were regulated, and the islet cells were protected by L. rhamnosus CCFM0528. These findings demonstrated the antidiabetic effect of L. rhamnosus CCFM0528 on mice with type 2 diabetic induced by a high-fat diet and streptozotocin. Our study suggested that L. rhamnosus CCFM0528 may be a promising therapeutic agent in treating type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 318-326
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 318-326
نویسندگان
Pei Chen, Qiuxiang Zhang, Hui Dang, Xiaoming Liu, Fengwei Tian, Jianxin Zhao, Yongquan Chen, Hao Zhang, Wei Chen,