کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624773 | 1494556 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
β-Casomorphins are opioid like bioactive peptides released on digestion of β-casein of milk. In the present study in vivo impact of consumption of β-casomorphins (BCM-7/5) was evaluated on immune response of murine gut. The peptides were given to mice through oral intubation at a dose of 7.5âÃâ10â8âmol/day/animal for 15âdays. Oral administration of both peptides individually increased (pâ<0.01) phenotypic expression of inflammation associated molecules (MPO, MCP-1, IL-4 and histamine), humoral immune response (IgE, IgG, IgG1/IgG2a), infiltration of leucocytes in intestinal villi and mRNA expression of toll like receptors (TLR-2 and TLR-4) in mice gut. However, no changes in sIgA, IgA+ and goblet cell numbers were recorded. These results clearly indicate that consumption of β-casein derived peptides BCM-7/5 induce inflammatory immune response in gut, most likely through Th2 pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 150-160
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 150-160
نویسندگان
Mohammad Raies Ul Haq, Rajeev Kapila, Vamshi Saliganti,