کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624774 | 1494554 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo](/preview/png/7624774.png)
چکیده انگلیسی
Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements. The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment. The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 327-335
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 327-335
نویسندگان
Petra MatouÅ¡ková, Hana BártÃková, Iva BouÅ¡ová, Barbora Szotáková, Jan Martin, Jana Skorkovská, Veronika HanuÅ¡ová, Veronika Tománková, Eva Anzenbacherová, Barbora LiÅ¡ková, Pavel Anzenbacher, Lenka Skálová,