کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624888 | 1494556 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Citrus junos Tanaka peel extract attenuates experimental colitis and inhibits tumour growth in a mouse xenograft model
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The inhibitory effects of yuja peel extract (Citrus junos Tanaka) on experimental colitis and colorectal cancer cells were evaluated. Yuja peel extracted with 70% ethanol (YPEE) reduced LPS-induced secretion of nitric oxide (NO), tumour necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and interleukin-6 (IL-6) by reduction of cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), and p38 phosphorylation in RAW264.7 cells. YPEE at 100âmg/(kg·day) also reduced both disease activity index (DAI) and colon shortening induced by Dextran sulphate sodium (DSS) in mice. COX-2 expression was decreased in colon tissue by YPEE. In addition, YPEE induced apoptotic body appearance in HT-29 colorectal cancer cells via decreasing COX-2. Furthermore, YPEE at 100âmg/(kg·day) inhibited tumour growth in tumour xenografts, which was accompanied by reduced COX-2 expression in colon tissue. Taken together, Yuja may be useful in preventing colitis and colorectal cancer via reduction of COX-2 expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 301-308
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 301-308
نویسندگان
Sung Hee Kim, Eun Ju Shin, Haeng Jeon Hur, Jae Ho Park, Mi Jeong Sung, Dae Young Kwon, Jin-Taek Hwang,