کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624913 1494557 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absolute bioavailability, pharmacokinetics and excretion of 5,7,3′,4′-tetramethoxyflavone in rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Absolute bioavailability, pharmacokinetics and excretion of 5,7,3′,4′-tetramethoxyflavone in rats
چکیده انگلیسی
The compound 5,7,3′,4′-Tetramethoxyflavone (TMF) is one of the major methoxyflavones identified in Kaempferia parviflora with several bioactivities, such as anti-allergic activity, antifungal and anti-inflammatory effects; however the information on oral bioavailability, pharmacokinetics and excretion of TMF is still absent. This study is designed to investigate the bioavailability, pharmacokinetics, and excretion of TMF in rats. After oral administration of 50 mg/kg TMF, the Cmax, Tmax, and T1/2 were calculated as 0.79 ± 0.30 μg/ml, 190.34 ± 24.50 min, and 273.76 ± 90.23 min, respectively. The bioavailability of TMF was estimated as 14.3% based on the AUCs of oral and IV administration. In excretion study, up to 48 h, 0.81% of the oral administered TMF was excreted as unconverted form fecal excretion and 0.05% from urinary excretion; it suggested that TMF mainly excreted as the metabolites form. The data presented in this study could provide useful information for the clinical applications of TMF in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 7, March 2014, Pages 136-141
نویسندگان
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