کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624932 | 1494554 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass
ترجمه فارسی عنوان
ویژگی های شیمیایی و فعالیت ضد التهابی لوتئولین گلیکوزیدهای جدا شده از لیمونراز
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Flavonoids from lemongrass - Cymbopogon citratus (DC.) Stapf - leaves infusion, a commonly consumed beverage for the treatment of inflammatory-related conditions, were investigated in this work. Luteolin O-, C- and O,C-glycosides were isolated and identified by nuclear magnetic resonance, being the cassiaoccidentalin B structure fully characterized for the first time in lemongrass. The anti-inflammatory activity of luteolin and its glycosides was evaluated in lipopolysaccharide-stimulated macrophages. Luteolin glycosides demonstrated less cytotoxicity than luteolin itself. Although glycosylation decreases luteolin anti-inflammatory properties, being higher to C-glycosylation, an inhibitory effect on inflammatory mediator production (nitric oxide and IL-1β) was verified for the luteolin 7-O-β-glucopyranoside, without cytotoxic effects. Therefore, luteolin glycosides from lemongrass infusion are evidenced as a less toxic alternative to current anti-inflammatory drugs with promising use in pharmaceutical and food supplement industries. Additionally, this work establishes structure-activity relationships, which constitutes valuable information in the design of anti-inflammatory luteolin glycosides devoid of toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 436-443
Journal: Journal of Functional Foods - Volume 10, September 2014, Pages 436-443
نویسندگان
Vera Francisco, Artur Figueirinha, Gustavo Costa, Joana Liberal, Maria Celeste Lopes, Carmen GarcÃa-RodrÃguez, Carlos F.G.C. Geraldes, Maria T. Cruz, Maria T. Batista,