کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7625092 1494556 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of β-sitosterol oral administration on the proliferation and differentiation of neural stem cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Effects of β-sitosterol oral administration on the proliferation and differentiation of neural stem cells
چکیده انگلیسی
Considering the presence of β-sitosterol in different functional foods and the potential role of neural stem cells (NSCs) in treating neurodegenerative diseases, this study was designed to evaluate the effects of oral administration of β-sitosterol on proliferation and differentiation of NSCs. Adult mice were divided into three groups. For 2 weeks, the control group received vehicle and the low and high dose groups received 33 and 99 mg/kg/day of β-sitosterol, respectively. Harvested NSCs from the subventricular zone (SVZ) were plated in neurosphere culture and the size and number of resulting neurospheres, and also their in vitro differentiation, were evaluated. β-Sitosterol at 99 mg/kg/day significantly increased proliferation of NSCs as evidenced by their neurosphere forming frequency (719.2 ± 53.65) compared to the control group (457.6 ± 21.35). Mean neurosphere diameter was significantly larger in both high and low dose β-sitosterol groups compared to the control group. β-Sitosterol did not affect in vitro differentiation of NSCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 252-258
نویسندگان
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