کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7625139 | 1494553 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of ergosterol-enriched extracts obtained from Agaricus bisporus on cholesterol absorption using an in vitro digestion model
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of ergosterol-enriched extracts obtained from Agaricus bisporus on cholesterol absorption using an in vitro digestion model Effect of ergosterol-enriched extracts obtained from Agaricus bisporus on cholesterol absorption using an in vitro digestion model](/preview/png/7625139.png)
چکیده انگلیسی
Ergosterol-enriched extracts obtained from Agaricus bisporus were incorporated into lard, butter and white chocolate as food carriers to study their potential as ingredients with hypocholesterolemic properties to design functional foods. Lard was selected and supplemented with several concentrations of cholesterol and ergosterol, beta-sitosterol (as control) and two types of ergosterol-enriched extracts obtained by supercritical fluid extraction (SFE) and accelerated solvent extraction (ASE). The prepared food combinations were submitted to a specific in vitro digestion model, their dietary mixed micelle (DMM) fractions isolated and administrated to Caco2 cell cultures. Ergosterol was as effective as some phytosterols such as sitosterol, in the displacement of cholesterol from the DMMs when applied to the food matrix in a ratio (1:2, w/w, cholesterol:sterol). The ASE extract was not effective but addition of the SFE extract provoked a 67% reduction in the DMM cholesterol content. Lard supplementation with fungal beta-glucans able to bind bile-acids enhanced the cholesterol displacement from the DMMs induced by the sterols although it also reduced ergosterol incorporation. Fungal sterols also impaired proper cholesterol transport through Caco2 monolayers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 589-597
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 589-597
نویسندگان
Alicia Gil-RamÃrez, Alejandro Ruiz-RodrÃguez, Francisco R. MarÃn, Guillermo Reglero, Cristina Soler-Rivas,