کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7633588 | 1494705 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
By employing proteomic analyses of eluted peptides from breast cancer cells, the current study has built an initial HLA-I-typed antigen collection for breast cancer research. It was also determined that immunogenic epitopes can be identified using established cell lines and that shared immunogenic peptides can be found in different cancer types such as breast cancer and leukemia. Importantly, out of 3196 eluted peptides that included duplicate peptides in different cells 89 peptides either contained mutation in their sequence or were derived from aberrant translation suggesting that mutation-containing epitopes are on the order of 2-3% in breast cancer cells. Finally, our results suggest that interfering with MHC class I function is one of the mechanisms of how tumor cells escape immune system attack.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 176, 30 March 2018, Pages 13-23
Journal: Journal of Proteomics - Volume 176, 30 March 2018, Pages 13-23
نویسندگان
Dmitri V. Rozanov, Nikita D. Rozanov, Kami E. Chiotti, Ashok Reddy, Phillip A. Wilmarth, Larry L. David, Seung W. Cha, Sunghee Woo, Pavel Pevzner, Vineet Bafna, Gregory G. Burrows, Juha K. Rantala, Trevor Levin, Pavana Anur, Katie Johnson-Camacho,