Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses

► 20% of the Leishmania donovani proteome identified across the 3 stress conditions ► Parasites reorganize the redox homeostasis and trypanothione metabolism during stress. ► Changes in oxidative phosphorylation, superoxide metabolism and respiration observed ► Maximum changes in the proteome observed upon exposure to peroxynitrile stress ► Explored how L. donovani parasites adapt the stress during early stage of infection