The proteomics of heavy metal hyperaccumulation by plants

► Hyperaccumulators have a high capability to take up heavy metals from the soil. ► Hyperacumulators have a faster and effective root-to-shoot translocation of metals. ► Protein variation helps identify the major players in hyperaccumulators. ► Protein biomarkers can help to design the plant hyperaccumulator ideotype. ► Data networks on hyperaccumulators help to understand plant metal homeostasis.