Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production

► Two strains of Streptomyces avermitilis were used for comparison. ► A global protein abundance analysis using 2DE-based proteomics were carried out. ► Significant protein modulation occurred in the comparison group In-P vs In-NP. ► The comparison group In-NP vs W-NP revealed some information about the mutation.