Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine circoviru

► The cellular protein profile of PCV2-infected PAMs was investigated by iTRAQ. ► Some significantly regulated proteins and pathways were related to pathological responses of PCV2 infection. ► The data will be helpful for defining the molecular mechanism of replication and pathogenesis of PCV2.