Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

► Omic integration generates a holistic profile of cellular perturbations. ► Pharmacokinetics is necessary to compliment the systems omics approach. ► Cyclosporine A induced-stress is not linked to primary pharmacology. ► Approach will be useful for the development of better safety prediction models.