Early storage lesions in apheresis platelets are induced by the activation of the integrin αIIbβ3 and focal adhesion signaling pathways

► Platelet storage lesions occur within 24 h after apheresis. ► Integrin-alphaIIb beta3 and focal adhesion signaling are involved. ► Platelet storage media affects protein modifications in stored platelets. ► Protein de novo synthesis possible in stored platelets.