کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7668411 1495166 2018 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of a novel lanthanide fluorescent probe (TbIII-dtpa-bis(2,6-diaminopurine)) and its application to the detection of uric acid in urine sample
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Design and synthesis of a novel lanthanide fluorescent probe (TbIII-dtpa-bis(2,6-diaminopurine)) and its application to the detection of uric acid in urine sample
چکیده انگلیسی
A novel fluorescent probe, Tb-dtpa-bdap, is designed based on the principle of complementary base pairing and synthesized for uric acid detection. The affecting factors, including solution pH, uric acid concentration and interfering substances, on the detection of uric acid using this prepared probe are examined. Under the optimized conditions, the fluorescence intensities of Tb-dtpa-bdap solution towards different uric acid concentrations show a linear response in the range from 1.00 × 10−5 mol·L−1 to 5.00 × 10−5 mol·L−1 with the correlation coefficient (R2) of 0.9877. And the obtained limit of detection (LOD) is about 5.80 × 10−6 mol·L−1, which is much lower than the level of uric acid in actual urine. The mechanism on the detection of uric acid by using Tb-dtpa-bdap is inferred according to the above mentioned experimental results. The facts demonstrate that the proposed fluorescent probe may be successfully applied for the determination of uric acid in human urine samples.267
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 203, 5 October 2018, Pages 461-471
نویسندگان
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