کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
767132 | 897149 | 2012 | 10 صفحه PDF | دانلود رایگان |

Apoptosis is a biological process crucial for the development and maintenance of healthy living organism. A deregulated apoptosis underlies many diseases, including cancer. Under hypoxic conditions, p53 starts to accumulate and competes with HIF-1 for their common binding target p300. This can lead to the repression of HIF-1, and trigger the apoptotic derive. In addition apoptosis is accompanied by an enhancement of potassium (K+) fluxes, which in turn create a low-potassium intracellular micro-environment, which cooperates to the activation of caspases, the final actors of the apoptotic cascade. Based on this scenario, we elaborate a dynamical model aimed at resolving the complex dynamical interplay between the aforementioned processes. In the ideal continuum limit, the model reduces to a system of coupled differential equations, whose dynamics is analytically inspected.
► We model the process of apoptosis and angiogenesis.
► We deal with the angiogenetic switch in tumor progression.
► We focus on apoptosis induced by hypoxia.
► A dynamical transition is found between life/death states.
► Conclusions are benchmarked to the experimental literature.
Journal: Communications in Nonlinear Science and Numerical Simulation - Volume 17, Issue 4, April 2012, Pages 1795–1804