In vitro DNA binding, pBR322 plasmid cleavage and molecular modeling study of chiral benzothiazole Schiff-base-valine Cu(II) and Zn(II) complexes to evaluate their enantiomeric biological disposition for molecular target DNA

Synthesis, characterization, DNA binding and pBR322 cleavage studies of enantiomeric L- and D-benzothiazole Schiff base-valine Cu(II) and Zn(II) complexes were investigated. L-enantiomeric Cu(II) complex recognize minor groove and cleave DNA via oxidative pathway.