Spectroscopic and DFT study of solvent effects on the electronic absorption spectra of sulfamethoxazole in neat and binary solvent mixtures

- The solvatochromism of sulfamethoxazole (SMX) was studied by UV-vis spectroscopy.
- The spectral shifts of SMX were analyzed in neat and binary solvent mixtures.
- The multiparametric equation of Kamlet and Taft explain the observed solvent effect.
- The TD-DFT simulated UV-Vis spectra were in good agreement with the experimental ones.
- Preferential solvation is observed in all analyzed binary mixtures.