Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,N′,N″-trisubstituted phenylguanidines

The DNA binding potency of the synthesized guanidines (1-6) were determined by UV-Vis spectrophotometer and cyclic voltammeter by keeping the concentration of the compounds constant (A) while varying the amount of DNA (B-H). All the compounds showed electrostatic mode of interaction with DNA having impressively high binding constants values (9.9 × 104-1.3 × 105 (M−1)). The compounds also showed good antioxidant activities. These two parameters are helpful to design new anticancer drugs.