کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7672650 | 1495251 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,Nâ²,Nâ³-trisubstituted phenylguanidines
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,Nâ²,Nâ³-trisubstituted phenylguanidines Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,Nâ²,Nâ³-trisubstituted phenylguanidines](/preview/png/7672650.png)
چکیده انگلیسی
The DNA binding potency of the synthesized guanidines (1-6) were determined by UV-Vis spectrophotometer and cyclic voltammeter by keeping the concentration of the compounds constant (A) while varying the amount of DNA (B-H). All the compounds showed electrostatic mode of interaction with DNA having impressively high binding constants values (9.9Â ÃÂ 104-1.3Â ÃÂ 105 (Mâ1)). The compounds also showed good antioxidant activities. These two parameters are helpful to design new anticancer drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 117, 3 January 2014, Pages 264-269
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 117, 3 January 2014, Pages 264-269
نویسندگان
Rukhsana Gul, Amin Badshah, Azim Khan, Asif Junaid, Muhammad Khawar Rauf,