Spectroscopic studies on the interaction between tetrandrine and two serum albumins by chemometrics methods

The interactions of tetrandrine (TETD) with two serum albumins (BSA and HSA) have been investigated using multispectroscopic and chemometrics methods at different temperatures under imitated physiological conditions. These spectra data measured were further analyzed by multivariate curve resolution-alternating least squares (MCR-ALS) and the concentration profiles for three species (BSA/HSA, TETD and TETD-BSA/HSA) existed in the interaction procedure.