Simultaneous determination of some cholesterol-lowering drugs in their binary mixture by novel spectrophotometric methods

Four simple, specific, accurate and precise spectrophotometric methods manipulating ratio spectra were developed and validated for simultaneous determination of simvastatin (SM) and ezetimibe (EZ) namely; extended ratio subtraction (EXRSM), Simultaneous ratio subtraction (SRSM), ratio difference (RDSM) and absorption factor (AFM).