کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7692264 | 1496277 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rapid tin-mediated access to a lysophosphatidylethanolamine (LPE) library: Application to positional LC/MS analysis for hepatic LPEs in non-alcoholic steatohepatitis model mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LPAiPrOHtriphenylmethylDPPELPLDMFlysophosphatidylethanolamineLPELPCLPILPS1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine - 1،2-Dipalmitoyl-sn-glycero-3-phosphoethanolaminelysophosphatidic acid - اسید لیسفسفیدیدIsopropanol - ایزوپروپانول، ایزوپروپیل الکلdimethylformamide - دی متیل فرمالیدHead group - سر گروهphosphatidylethanolamine - فسفاتیدیلتانولامینPhospholipid - فسفولیپیدLysophosphatidylcholine - لیزوفسفاتیدیل کولینLysophosphatidylserine - لیسفسفاتیدیلسرینlysophospholipid - لیسفسفلیپیدLysophosphatidylinositol - لیسفوسفیدیدیلینواستول
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Even though lysophospholipids have attracted much interest in recent years on account of their unique bioactivity, research related to lysophospholipids is usually hampered by problems associated with standard sample preparation and discrimination of regioisomers. Herein, we demonstrate a quick tin-chemistry-based synthetic route to lysophosphatidylethanolamines (LPEs) and its application in the positional analysis of hepatic LPEs in non-alcoholic steatohepatitis (NASH) model mice. We found that the preference of hepatic LPE regioisomer largely depends on the unsaturation of acyl chain in both control and NASH model mice. In addition, hepatic C18:2-LPE and C20:5-LPE levels were significantly lower in the NASH model mice than those in the control. The LC/MS technique based on the library of LPE regioisomers allows an accurate observation of hepatic LPE metabolism and might provide useful information to elucidate yet ambiguous pathogenesis of NASH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 200, October 2016, Pages 133-138
Journal: Chemistry and Physics of Lipids - Volume 200, October 2016, Pages 133-138
نویسندگان
Takayuki Furukawa, Hirotoshi Fuda, Satoshi Miyanaga, Chinatsu Watanabe, Hitoshi Chiba, Shu-Ping Hui,