کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7692328 | 1496291 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
ترجمه فارسی عنوان
تحویل دارو به وسیله داروهای کربوهیدرات: سنتز و مشخص کردن ترکیبات جدید چربی
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کلمات کلیدی
مانوپیرانوزید، گالاتوپیرانوزید، لیپیدها، لیپید کنجد، سنتز، تحویل مواد مخدر،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM) and p-aminophenyl-α-d-galactopyranoside (PAPG) with spacer in between the quaternary nitrogen atom and the sugar unit is developed. In addition, a new class of neutral glycolipid conjugates, such as PAPM-lipids or PAPG-lipids conjugates was also synthesized for targeting drugs to receptors. The precipitation-inhibition assay showed that conjugate of PAPM inhibited the concanavalin A and invertase aggregation. This binding inhibition study of a synthesized compound suggests that conjugates of PAPM can be potentially used to target mannose receptors. In addition, a higher transfection was obtained by mixing PAPM with pSV-β-gal reporter gene and incubating with mannose binding protein/receptor expressing A549 cells. The coexistence of both mannose group and a net positive charge may result in improved transfection efficiency in cells expressing mannose binding proteins/receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 186, February 2015, Pages 30-38
Journal: Chemistry and Physics of Lipids - Volume 186, February 2015, Pages 30-38
نویسندگان
Moghis U. Ahmad, Shoukath M. Ali, Ateeq Ahmad, Saifuddin Sheikh, Paul Chen, Imran Ahmad,