Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis

► FLZ loaded SLNs and NLCs are compatible with topical application. ► NLCs have shown good ability to increase drug retention in various skin layers. ► It presented sustained and controlled release of drug without systemic absorption. ► NLCs serve as effective carriers in treatment of skin diseases via topical route.