کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7692629 1496312 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer and sphingolipid storage disease therapy using novel synthetic analogs of sphingolipids
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Cancer and sphingolipid storage disease therapy using novel synthetic analogs of sphingolipids
چکیده انگلیسی
► Novel sphingolipid analogs inhibit the hydrolysis of ceramide or its conversion to complex sphingolipids. ► Synthetic analogs were effective in killing cancer cells in vitro and in vivo. ► Analogs were tested for two therapeutic approaches for sphingolipidoses: substrate reduction therapy and chaperone therapy. ► Synthetic fluorescent sphingolipids were developed for the analysis of sphingolipid metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 165, Issue 4, May 2012, Pages 462-474
نویسندگان
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