Modulation of the domain topography of biphasic monolayers of stearic acid and dimyristoyl phosphatidylcholine

► The domain shape in monolayers of DMPC and SA at pH4 depends on composition. ► There is a shape change from flower-like to circular domains at 40-45 mole% of SA. ► This change is related to domain density, thus to domain nucleation. ► We identified the factors determining domain shape and distribution in this system. ► This could be a way of self-regulating the membrane properties.