Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface

► We report novel diacylacetate quaternized amine (AQ) zwitterionic lipids. ► AQ lipids exhibit transition temperatures similar to those of PE lipids. ► AQ lipids interact with anions according to the Hofmeister series. ► AQ liposomes demonstrate similar in vivo properties to DSPC liposomes. ► AQ lipids have distinct biophysical properties from PC lipids that may be useful in drug delivery.