کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7693762 1496466 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescence-guided surgery of cancer: applications, tools and perspectives
ترجمه فارسی عنوان
جراحی سرطان فلورسانس: برنامه های کاربردی، ابزار و چشم انداز
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی
Thousands of patients die each year from residual cancer that remains following cytoreductive surgery. Use of tumor-targeted fluorescent dyes (TTFDs) to illuminate undetected malignant tissue and thereby facilitate its surgical resection shows promise for reducing morbidity and mortality associated with unresected malignant disease. TTFDs can also improve i) detection of recurrent malignant lesions, ii) differentiation of normal from malignant lymph nodes, iii) accurate staging of cancer patients, iv) detection of tumors during robotic/endoscopic surgery (where tumor palpation is no longer possible), and v) preservation of healthy tissue during resection of cancer tissue. Although TTFDs that passively accumulate in a tumor mass provide some tumor contrast, the most encouraging TTFDs in human clinical trials are either enzyme-activated or ligand-targeted to tumor-specific receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 45, August 2018, Pages 64-72
نویسندگان
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