کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7693765 | 1496465 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
ترجمه فارسی عنوان
ژنومیک های مصنوعی: یک اقدام جدید برای محاسبه اصول اولیه ژنوم و ایجاد توابع جدید
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10Â 000Â bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 46, October 2018, Pages 56-62
Journal: Current Opinion in Chemical Biology - Volume 46, October 2018, Pages 56-62
نویسندگان
Daniel Schindler, Junbiao Dai, Yizhi Cai,