کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7693979 1496470 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epitranscriptomics: regulation of mRNA metabolism through modifications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Epitranscriptomics: regulation of mRNA metabolism through modifications
چکیده انگلیسی
Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N6-methyladenosine (m6A), paved the way for the deciphering of other types of mRNA modifications, such as N1-methyladenosine (m1A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 41, December 2017, Pages 93-98
نویسندگان
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