کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7694175 1496479 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases
ترجمه فارسی عنوان
عامل دارویی فعلی در مقابل وعده داروهای نسل بعدی برای بهبود بیماری های غیروابسته و / یا بیماری های تجمع
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی
The list of protein aggregation-associated degenerative diseases is long and growing, while the portfolio of disease-modifying strategies is very small. In this review and perspective, we assess what has worked to slow the progression of an aggregation-associated degenerative disease, covering the underlying mechanism of pharmacologic action and what we have learned about the etiology of the transthyretin amyloid diseases and likely amyloidoses in general. Next, we introduce emerging therapies that should apply more generally to protein misfolding and/or aggregation diseases, approaches that rely on adapting the protein homeostasis or proteostasis network for disease amelioration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 32, June 2016, Pages 10-21
نویسندگان
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