کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7694269 1496480 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems
ترجمه فارسی عنوان
خیاطی آنزیمی پلی کتید و پپتید در سیستم های تیتومپلت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی
Non-ribosomal peptide synthetases (NRPS) and type I polyketide synthases (PKS) are versatile thiotemplate systems for the programmed assembly of biosynthetic building blocks. Typically, the post-PKS/NRPS enzymes tailor the resulting chains to yield the bioactive natural product scaffolds. However, more and more examples have surfaced showing that important structural modifications take place while the intermediates are still bound to the assembly line. A growing number of enzymatic domains and trans-acting enzymes as well as their recruiting areas in the modules have been identified and characterized. In addition to the widespread on-line alkylations, hydroxylations and heterocyclizations into oxazole/thiazole residues, on-line modifications lead to a variety of ring systems such as cycloethers, lactones, lactams, glutarimides, cyclopropanes, decalins and cyclic biaryls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 31, April 2016, Pages 82-94
نویسندگان
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