Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher

- SpyTag and SpyCatcher are peptide-protein partners that lock together covalently.
- Reaction occurs in a wide range of protein contexts, buffers and temperatures.
- One-to-one linkage enabled dramatic enzyme resilience and rapid vaccine generation.
- Network linkage created tools for stem cell culture and living biomaterials.