Butyrolactone signalling circuits for synthetic biology

- γ-Butyrolactone (GBL) hormones regulate antibiotic production in many Streptomyces species.
- GBL-based systems could be used to design orthogonal switches in synthetic biology.
- The GBL receptor ScbR has been used in mammalian synthetic switches.
- The chemical diversity of GBLs could be used for multi-input/multi-channel devices.
- Understanding natural GBL circuit complexity will guide the design of new systems.