LOV-based reporters for fluorescence imaging

- Flavin-binding LOV domains have been engineered as green fluorescent reporters.
- Several LOV-based FPs are available with different photophysical properties.
- LOV-based FPs can circumvent limitations commonly associated with GFP-related FPs.
- LOV fluorescence has been exploited for various imaging and biosensor applications.
- Their properties also offer new possibilities in cancer therapy and optogenetics.