Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires

- Next-generation sequencing of peripheral B cells (BCR-seq) in health and disease states.
- Serum antibody proteomics (Ig-seq) complements BCR-seq in analyzing endpoint functionality.
- Advances in the pairing and NGS of antibody heavy chain and light chain (VH:VL) sequences.
- Combined, BCR-seq and Ig-seq provide a clear advance in antibody discovery.