Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

- Intracellular aminopeptidases generate antigenic peptides.
- Their activity can alter cellular immune responses and predisposition to disease.
- Their enzymatic activity is regulated by pathogens and polymorphic variation.
- Chemical inhibition or activation can lead to novel immunotherapeutic treatments.
- The first generation chemical tools to achieve their regulation are in development.