Turning the spotlight on protein-lipid interactions in cells

- In vivo photocrosslinking reactions are powerful for studying protein-lipid interactions.
- A variety of photoactivatable lipid probes have been developed for studying lipid-binding proteins in vitro and in vivo.
- Photoactivatable and clickable lipid probes serve as new tools for globally identifying lipid-binding proteins in vivo.
- Photoactivatable fatty acids can also be used to capture lipidation-mediated protein-protein interactions in vivo.