Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions

► Expansion of the CaaX paradigm by biochemical and computational methodologies. ► Improvement of chemical biology tools to define mammalian prenylome. ► Identification of proteins that regulate entry into prenylation pathway. ► Involvement of mammalian prenyltransferases in bacterial pathogenesis. ► Clinical evaluation of inhibitors for cancer and premature aging diseases.